Brain Perfusion Changes after HBOT in Children with Autism

KINACI Cem¹, ALAN Mustafa², HATIPOGLU Kadir³
¹DAN! Practitioner and Nuclear Medicine Physician, IMC Hospital, Mersin, Turkey.
²Aerospace Medicine Physician, Baromed Hyperbaric Center, Ankara, Turkey.
³Diving Medicine and Pulmonary Disease Physician, Gulhane Military Medical Academy, TSK RehabilitationCenter, Ankara, Turkey.

Background: Autism is the most common disease of the PervasiveDevelopmental Disorders. Impaired detoxification and heavy metal burden are predisposing factors forautism. Many cases of autism today are, in fact, cases of gut-brain inflamation secondary to toxic heavy metal poisoning.

Materials/Methods: This study shows the brain perfusion changes secondary to brain inflamation and effects of HBOT in 108 children with autism (85 males, 23 females) between the ages 3-12. We performed a retrospectivereview in search of DMSA provocated urine toxic metals profiles, MR imaging and common functional abnormalitieswith brain Single-Photon Emission Computed Tomography (SPECT) of these children. We applied 50 sessions HBOT for each patient at 1.5 ATA for 60 minutes/daily. Then we compared the results of SPECT scans before and after HBOT.

Picture 1: DMSA Provocated Urine test
Results/Discussion: All 108 cases had elevated or highly elevated levels of lead and 61 of them had mercury and most of them were in company with some other toxic heavy metals (Picture 1). Before HBOT all of the patients were revealed focal areas of decreased perfusion intemporal lobe of the brain. We also detected decreased perfusion in 79 males and in 16 females at frontal lobes and in 54 males and in 12 females at other areas of the brain. By contrast all patients had normal MRI findings.
After HBOT, all patient’s SPECT scan findings has dramatically improvement; 84.70% (72 of 85) at temporal, 89.87% (71 of 79) at frontal and 79.63% (43 of 54) at the other areas in males and 73.91% (17 of 23) at temporal, 62.50% (10 of 16) at frontal and 58.33% (7 of 12) at the other areas in females. HBOT which now being used for autism is to address the neuroinflammatory component of the disorder. The use of HBOT is based on the latest research into its role in the control of inflammation (1).
Through these sessionswe make sure that the brains inactive cells develop to normal function. SPECT scanning can identify recoverable brain cells (idling neurons) (Pictures 2, 3)

Conclusions: After HBOT, extensive perfusion improvements involving the brain were found in this study. SPECT scans may be more sensitive in reflecting the pathophysiology of autism than MRI.

Literature:(1) Carl Nathan, Oxygen and the inflammatory cell.Nature 2003 vol 422 675-676.