HBOT and Chelation: An effective Combination for Treatment of Neuroinflamation in Children with Autism

Nuclear Medicine Department,
Acibadem / Sistina Hospital,

INTRODUCTION: A. S. is a 7 years old boy diagnosed with autism. Mother was 29 years old at birth. Delivery was vaginal and full term with no problem. He was a goodbaby, a good sleeper and a good eater. He didn’t crawl. He preferred round spinning toys. He had good eye contact and language comprehension. Family had seen thefirst signs at 2½ years old. He was not speaking ! Family history shows biochemical aftermath secondary to Gastrointestinal inflamation at all family members. Mother has zink deficiency and constipation. Father has zink deficiency and lactose intolerance. Maternal grand mother has high blood pressure, diabetes mellitus and astma. Paternal grand mother has high blood pressure. Maternal and paternal grand fathers have constipation.

METHODS: During consultation we looked to brain anatomy with Magnetic Resonance scan (MR) and brain function with perfusion SPECT scan (SPECT). He had abnormal SPECT revealing focal areas of decreased perfusion. By contrast he had normal MR findings (no signs of oxygen delivery problem to brain or signs of any infectious disease).
As a cause for neuroinflamation, A.S. had very elevated levels of lead in urine provocated with DMSA 30mg/kg.
The fact that heavy metals are neurotoxic, they destroy the nervous system and it is a well known fact within medical science. Studies show that autistic children have high levels of mercury and/or lead in their blood and tissues, Hyperbaric oxygen theraphy (HBOT) increases in blood flow independent of new blood vessel formation, decreasing levels of inflammatory biochemicals, up-regulation of key antioxidant enzymes and decreasing oxidative stress, increased oxygenation to functioning mitochondria, increased production of new mitochondria, by-passing functionally impaired hemoglobin molecules secondary to abnormal porphyrin production, Improvement of the immune system and the autoimmune system, decreasing the bacterial and yeast load systemically and in the gastrointestinal system, decreasing the viral load found systemically and the viral load in the gastrointestinal mucosa.
HBOT increases by eight-fold the number of circulating stem cells throughout the body, increases in the production of stem cells in thebone marrow with transfer to the central nervous system, increases direct production of stem cells by certain areas in the brain. Stem cells, also called progenitor cells, are crucial to the repair of injured tissues and organs. The possibility that oxidation also may help rid the body of heavy metals. As a result of both studies, we conclude that the areas with decreased perfusion were all neuroinflammatory areas (idling neurons) secondary to toxic overload. We planed to do “ ““ “HBOT HBOT HBOT + chelation chelation chelation combination” combination” combination” for treatment : HBOT for neuroinflamation and chelationtheraphy for lead intoxication.

RESULTS: In 26 months; after totally 90 sessions of HBOT at1.5 ATA with 100% oxygen for 60 minutes and using a special chelation protocol at the same time, he showed significiant improvement on speach, judgement, learning, fine motor and gross motor functions. He was more calm and happy.
Beter sleeping, beter behaviour and more interest with environment were other changes after the theraphy. Leadlevels were decreased from 45micg/g creatinin to 14 micg/g creatinin in DMSA provocated urine and control brain perfusion SPECT showed increased perfusion at the inflammatory areas, compairing with previous scan.

CONCLUSION: In this case, a combined treatment with “HBOT and chelation” showed a great success to decrease the symptoms secondary to neuroinflamation in children with autism.

REFERENCES: 1.Sallie Bernard, Albert Enayati, Teresa Binstock, Heidi Roger, Lyn Redwood, Woody McGinnis. Autism: A Novel Type of Mercury Poisoning. Medical Hypothesis2001, 56(4) 462-471. 2.Diana L Vargas, Caterina Nascimbene, Chitra Krishnan, Andrew W. Zimmerman, Carlos A. Pardo. Neuroglial Activation and Neuroinflamation in the Brain of Patients with Autism. Ann. Neurol. 2005 jan;57(1):67-81. 3.Carl Nathan. Oxygen and the inflammatory cell. Nature 2003 vol 422 675-676. 4.Theodore C. Rozema. The Protocol for the Safe and Effective Administration of EDTA and Other Chelating Agents for Vascular Disease, Degenerative Disease and Metal Toxicity. Journal of Advencement in Medicine Vol.10,Num.1, Spring 1997. 5.Cem KINACI, Serpilgül KINACI, Brain Perfusion SPECT Findings of Heavy Metal Intoxication in Children with Pervasive Developmental Disorders. 1st Balkan Congress of Nuclear Medicine Antalya-TURKEY April 04-08 2012. 6.Cem KINACI, Serpilgül KINACI, Mustafa ALAN, Does Brain Perfusion SPECT May Play a Role to Plan the Treatment of Neuroinflamation in the Children with Autism Spectrum Disorders ? 1st Balkan Congress of Nuclear Medicine Antalya-TURKEY April 04-08 2012. 7.Cem KINACI, Serpilgül KINACI, Mustafa ALAN, Emin ELBUKEN The Effects of Hyperbaric Oxygen Theraphy in the Children with Autism Spectrum Disorders. 2009 UHMS Annual Scientific Meeting, Las Vegas, NV- USA, June 25 - 27, 2009. 8.Cem KINACI, Serpilgül KINACI, Perfusion Changes Secondary to Heavy Metal Intoxication, Detected by Brain Perfusion Spect in Children With Autism. Autism Neuroscience Conference, Royal Society, London, UK, October 6-7, 2008. 9.Cem KINACI, Brain SPECT scanning: How it makes a difference in Autism. 1st Istanbul International Autism Conference, Istanbul – Turkey, june 14 – 16, 2008. 10.Cem KINACI, Mustafa ALAN, Kadir HATIPOGLU Brain Perfusion Changes After Hyperbaric Oxygen Theraphy in The Children With Autism. 33rd Annual Scientific Meeting of the European Underwater and Baromedical Society on Diving & Hyperbaric Medicine Sharm el-Sheikh, Sinai, Egypt , September 08-15, 2007.